The Skeleton Twins

Official synopsis with review below:
2013, 90 minutes, color, U.S.A.
Living separate lives on opposite sides of the country, estranged siblings Maggie and Milo are at the end of their ropes. But after a moment of crisis reunites them, Milo goes to spend time with Maggie in the small New York town where they grew up. A dental hygienist, Maggie struggles with her unhappy marriage to the painfully good-natured Lance, while Milo tracks down Rich, the English teacher with whom he shares a checkered past. Adrift and wondering how they ended up so far from who they were supposed to be, the siblings try to patch things up.

Craig Johnson’s second feature sensitively explores these lives of quiet desperation with remarkable finesse. It unfolds a rich backstory through subtle interactions between its characters and finds the agility to be funny, melancholic, touching, and devastating within the space of a single scene. Kristin Wiig and Bill Hader give astonishing, dramatic performances. Their connection to the characters and to each other is magical…and funny (Maggie cleaning Milo’s teeth proves that nothing promotes sibling reconciliation like nitrous oxide).

The twins’ father once told them to stick together no matter what. The Skeleton Twinsis about discovering what that means. 
Director: Craig Johnson
Screenwriters: Craig Johnson, Mark Heyman
Producers: Stephanie Langhoff, Jennifer Lee, Jacob Pechenik
Executive Producers: Mark Duplass, Jay Duplass, Jared Ian Goldman
Cinematographer: Reed Morano
Production Designer: Ola Maslik
Editor: Jennifer Lee
Composer: Nathan Larson
Principal Cast: Bill Hader, Kristen Wiig, Luke Wilson, Ty Burrell, Boyd Holbrook, Joanna Gleason

Review by Jason Brown:

The Skeleton Twins is a highly entertaining tragic comedy. It features very strong performances by Bill Hader and Kristin Wiig. Bill portrays the melancholic Milo with depth and humor that hides his pain. Wiig plays her character, Maggie, in an understated way but still delivers a strong performance as the troubled sister trying to be happy in an allegedly storybook marriage. One of the best lines from Milo about Maggie is that she is a "restless housewife with whitish tendencies" delivered during one of the more touching moments of the movie. Trust me when I say that scene will stay in your memory! Also - keep an eye and ear out for the duo lip syncing to a well known Starship power ballad! I think this movie will do really well in general release - still no word on who will pick it up. If you do get a chance to see this movie you will be glad you did. I am also hopefull that this can allow Hader and Wiig an entry into more dramatic roles.